To report SUSPECTED ADVERSE REACTIONS, Contact Benuvia Operations, LLC at

1 (844)-558-8289, or email Info@Benuvia.com,
or contact the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

SYNDROS CARES® Free Trial Voucher Card
(Terms and Conditions apply)

  • This field is for validation purposes and should be left unchanged.
  • First bottle with first prescription is fully covered and immediately filled while the second prescription is pending insurance authorization
  • Health Care Provider may provide two separate prescriptions for the Patient to present to Pharmacy in order to take advantage of the “Free Trial Voucher” offer while insurance is being processed for the remaining full prescription.
    • Trial Voucher Card: Prescription Written for One (1) Bottle (30mL), will be free with SYNDROS CARES® Trial Voucher Program valid for one use per patient (regardless of insurance) which will be processed as a Primary claim using Bin 610600.
    • Discount Co-Pay Card for Commercially-Insured Patients: Written for full prescription (total remaining bottles needed) and process through the patient’s commercial insurance as the Primary claim and submitting the SYNDROS CARES® Discount CO-Pay Card as a Secondary Claim using BIN: 610600 as a coordination of benefits (COB).
    • Discount Card for a Cash-Paying Patient: To Process Uninsured Claims: Submit Primary claim using BIN: 610600.

    For support processing either the Free Trial Voucher or Discount Co-Pay Cards, please call SYNDROS CARES® at 877-369-5158

  • For commercially-insured and cash-paying patients only

Benuvia Operations, LLC Patient Services Center
Call 1-877-369-5158
Fax 1-844-793-4412

If you have been prescribed a Benuvia product, we are here to help you.
Take advantage of other resources and programs available to you such as:

  • Benuvia Operations, LLC’s SYNDROS CARES® Free Trial Voucher and/or Discount Card

SYNDROS CARES® Discount Card
(Terms and Conditions apply)

  • This field is for validation purposes and should be left unchanged.
  • If you have commercial insurance, you will pay as little as $0 Co-Pay for each prescription.
  • If you are cash-paying, you will receive up to a $400 discount per prescribed bottle.
  • If you have any questions pertaining to the use of this card, please call 1-877-369-5158.

SYNDROS CARES® Eligibility, Terms and Conditions

  • Co-Pay/Discount Card offers valid for commercially-insured and cash-paying patients only, except where prohibited by law.
  • Maximum Discount Card benefit of $400 off each new prescription bottle of SYNDROS (dronabinol) oral solution for cash-paying patients.
  • Savings offer not valid for any individual for whom any part of any prescriptions for SYNDROS is or will be covered by Medicaid, Medicare (including Medicare Advantage or Part D prescription Plans), any states’ prescription drug programs, or any other public payer program. If any other part of your prescription is paid by a non-governmental third-party payer, you attest to having disclosed this offer to your third-party payer.
  • Offers cannot be combined with any other coupon, certificate, voucher, rebate or similar offer.
  • Offers good only in the USA and Puerto Rico at participating retail pharmacies and cannot be redeemed at government-subsidized clinics.
  • Benuvia Therapeutics Inc. has the right to revoke or cancel these offers, or to change the rules of the program, without notice.
  • For a Free Trial Voucher, a new patient is defined as any patient that has not previously utilized a Free Trial Voucher Card
Important Safety Information

Important Safety Information

What is SYNDROS?

  • SYNDROS is a prescription medicine used in adults to treat:
    • Nausea and vomiting caused by anti-cancer medicine (chemotherapy) in people whose nausea and vomiting have not improved with usual anti-nausea medicines.
    • Loss of appetite (anorexia) in people with AIDS (Acquired Immune Deficiency Syndrome) who have lost weight.
SYNDROS is a controlled substance (CII) because it contains dronabinol which can be a target for people who abuse prescription medicines or street drugs. Keep your SYNDROS in a safe place to protect it from theft. Never give your SYNDROS to anyone else because it may cause death or harm them. Selling or giving away this medicine is against the law.

Do not take SYNDROS if you:

  • had an allergic reaction to dronabinol. Signs and symptoms of an allergic reaction to dronabinol include: swelling of the lips, hives, a rash over your whole body, mouth sores, skin burning, flushing, and throat tightness.
  • had an allergic reaction to alcohol.
  • are using a medicine that contains disulfiram (Antabuse) or metronidazole (Pylera, Flagyl, Flagyl ER, Nuvessa, Vandazole) or have taken or received a medicine that contains disulfiram or metronidazole in the last 14 days.

Before taking SYNDROS, tell your doctor about all of your medical conditions, including if you:

  • have or had heart problems.
  • have or had problems with drug abuse or dependence.
  • have or had problems with alcohol abuse or dependence.
  • have or had mental health problems including mania, depression or schizophrenia.
  • have had a seizure or have a medical condition that may increase your risk of having a seizure.
  • are pregnant or plan to become pregnant. SYNDROS may harm your unborn baby. Avoid the use of SYNDROS if you are pregnant.
  • are breastfeeding or plan to breastfeed. The Centers for Disease Control and Prevention recommends that mothers with HIV not breastfeed because they can pass the HIV through their breast milk to the baby. It is not known if SYNDROS passes into your breast milk. Talk to your doctor about the best way to feed your baby if you take SYNDROS. Do not breastfeed while taking SYNDROS and for 9 days after your last dose of SYNDROS if you are being treated for nausea and vomiting caused by anti-cancer medicine.
TELL YOUR DOCTOR ABOUT ALL THE MEDICINES YOU TAKE OR HAVE TAKEN IN THE LAST 14 DAYS, including prescription and over-the-counter medicines, vitamins, and herbal supplements. syndros and certain other medicines can affect each other, causing serious side effects.

How should I take SYNDROS?

  • See the "Instructions for Use" at the end of the Patient Information for detailed instructions about the right way to take SYNDROS.
  • Always use the oral syringe that comes with your SYNDROS oral solution to measure your prescribed dose. Ask your doctor or pharmacist to show you how to measure your prescribed dose.
  • Take SYNDROS exactly as your doctor tells you to. Your doctor may change your dose after seeing how it affects you. Do not change your dose unless your doctor tells you to change it.
  • Drink a full glass of water (6 to 8 ounces) right after you take your prescribed dose of SYNDROS oral solution.
  • If you are an adult with AIDS with loss of appetite and weight loss:
    • SYNDROS is usually taken 2 times each day, 1 hour before lunch and 1 hour before dinner. If you are elderly, or unable to tolerate this dose of SYNDROS, your doctor may prescribe SYNDROS to be taken 1 time each day, 1 hour before dinner or bedtime.
  • If you are an adult with nausea and vomiting caused by anti-cancer medicine:
    • SYNDROS is usually taken 1 to 3 hours before your chemotherapy treatment and then every 2 to 4 hours after chemotherapy for up to 4 to 6 doses each day. If you are elderly, your doctor may prescribe SYNDROS to be taken 1 to 3 hours before your chemotherapy, 1 time each day.
    • Take your first dose of SYNDROS on an empty stomach at least 30 minutes before eating. After your first dose of SYNDROS, you can take SYNDROS with or without food.
    • After your doctor has decided the dose of SYNDROS that is right for you, take SYNDROS exactly at the same time before or after meals during future chemotherapy treatment.
  • If you take too much SYNDROS, call your Poison Control Center at 1-800-222-1222 right away or go to the nearest emergency room.

What should I avoid while taking SYNDROS?

  • Do not drive, operate machinery, or do other dangerous activities until you know how SYNDROS affects you. SYNDROS taken with medicines that cause dizziness, confusion, and sleepiness may make these symptoms worse.

What is the most important information I should know about SYNDROS?

SYNDROS can cause serious side effects, including:

  • Worsening mental (psychiatric) symptoms. Psychiatric symptoms can worsen in adults who have mania, depression, or schizophrenia and who take SYNDROS. SYNDROS taken with medicines that cause psychiatric symptoms can worsen psychiatric symptoms. Elderly people who take SYNDROS may have a greater risk of having psychiatric symptoms. Tell your doctor if you have new or worsening mood symptoms, including symptoms of mania, depression, or schizophrenia.
  • Problems thinking clearly. Tell your doctor if you have trouble remembering things, concentrating, have increased sleepiness, or confusion. Elderly people may have a greater risk of having problems thinking clearly.
  • Changes in your blood pressure. SYNDROS may increase or decrease your blood pressure, especially when you start taking SYNDROS or when your dose is changed. Tell your doctor if you have signs or symptoms of changes in your blood pressure including: headaches, vision problems, dizziness, feeling lightheaded, fainting, or a fast heartbeat. Elderly people, especially those with dementia, and people with heart problems may have an increased risk of changes in blood pressure and an increased risk of falls.
  • Interactions with disulfiram or metronidazole. SYNDROS contains alcohol, which can cause you to have a reaction to medicines that contain disulfiram or metronidazole. You should not use any medicine that contains disulfiram (Antabuse) or metronidazole (Pylera, Flagyl, Flagyl ER, Nuvessa, Vandazole) if you take SYNDROS. You should not use a medicine that contains disulfiram or metronidazole for at least 14 days before you start taking SYNDROS and within 7 days after your last dose of SYNDROS. Tell your doctor if you have signs or symptoms of a reaction to disulfiram or metronidazole including: stomach-area (abdominal) cramping, nausea, vomiting, headache, and flushing.

What are the possible side effects of SYNDROS?

SYNDROS may cause serious side effects, including:

  • See "What is the most important information I should know about SYNDROS?"
  • Seizures. SYNDROS may increase your risk of seizures. Stop taking SYNDROS and call your doctor and get medical care right away if you have a seizure during treatment with SYNDROS.
  • Drug and alcohol abuse. You may have an increased risk of abusing SYNDROS if you have a history of drug or alcohol abuse or dependence, including marijuana. Tell your doctor if you develop abuse behaviors such as increased irritability, nervousness, restlessness or want more or higher doses of SYNDROS during your treatment.
  • Nausea, vomiting, or stomach-area (abdominal) pain. Tell your doctor if you have nausea, vomiting, or abdominal pain or if your nausea, vomiting, or abdominal pain gets worse during treatment with SYNDROS.

THE MOST COMMON SIDE EFFECTS OF SYNDROS INCLUDE:

  • stomach-area (abdominal) pain
  • dizziness
  • feeling extremely happy (euphoria)
  • nausea
  • overly suspicious or feeling people want to harm you (paranoid reaction)
  • sleepiness
  • abnormal thoughts
  • vomiting

THESE ARE NOT ALL THE POSSIBLE SIDE EFFECTS OF SYNDROS.

General information about the safe and effective use of SYNDROS

DO NOT USE SYNDROS FOR A CONDITION FOR WHICH IT WAS NOT PRESCRIBED. DO NOT GIVE SYNDROS TO OTHER PEOPLE, EVEN IF THEY HAVE THE SAME SYMPTOMS THAT YOU HAVE. IT MAY HARM THEM. YOU CAN ASK YOUR DOCTOR OR PHARMACIST FOR INFORMATION ABOUT SYNDROS THAT IS WRITTEN FOR HEALTH PROFESSIONALS.
Tell your healthcare provider about all the medicines and supplements you take, as some medicines may affect how SYNDROS works. Benuvia encourages you to report negative side effects of prescription drugs. To report SUSPECTED ADVERSE REACTIONS, contact Benuvia Operations, LLC at 1-844-558-8289 or to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

What is SYNDROS?

SYNDROS is a prescription medicine used in adults to treat:
  • Nausea and vomiting caused by anti-cancer medicine (chemotherapy) in people whose nausea and vomiting have not improved with usual anti-nausea medicines.
  • Loss of appetite (anorexia) in people with AIDS (Acquired Immune Deficiency Syndrome) who have lost weight.
SYNDROS is a controlled substance (CII) because it contains dronabinol which can be a target for people who abuse prescription medicines or street drugs. Keep your SYNDROS in a safe place to protect it from theft. Never give your SYNDROS to anyone else because it may cause death or harm them. Selling or giving away this medicine is against the law.

Important Safety Information

What is SYNDROS?

  • SYNDROS is a prescription medicine used in adults to treat:
    • Nausea and vomiting caused by anti-cancer medicine (chemotherapy) in people whose nausea and vomiting have not improved with usual anti-nausea medicines.
    • Loss of appetite (anorexia) in people with AIDS (Acquired Immune Deficiency Syndrome) who have lost weight.
SYNDROS is a controlled substance (CII) because it contains dronabinol which can be a target for people who abuse prescription medicines or street drugs. Keep your SYNDROS in a safe place to protect it from theft. Never give your SYNDROS to anyone else because it may cause death or harm them. Selling or giving away this medicine is against the law.

Do not take SYNDROS if you:

  • had an allergic reaction to dronabinol. Signs and symptoms of an allergic reaction to dronabinol include: swelling of the lips, hives, a rash over your whole body, mouth sores, skin burning, flushing, and throat tightness.
  • had an allergic reaction to alcohol.
  • are using a medicine that contains disulfiram (Antabuse) or metronidazole (Pylera, Flagyl, Flagyl ER, Nuvessa, Vandazole) or have taken or received a medicine that contains disulfiram or metronidazole in the last 14 days.

Before taking SYNDROS, tell your doctor about all of your medical conditions, including if you:

  • have or had heart problems.
  • have or had problems with drug abuse or dependence.
  • have or had problems with alcohol abuse or dependence.
  • have or had mental health problems including mania, depression or schizophrenia.
  • have had a seizure or have a medical condition that may increase your risk of having a seizure.
  • are pregnant or plan to become pregnant. SYNDROS may harm your unborn baby. Avoid the use of SYNDROS if you are pregnant.
  • are breastfeeding or plan to breastfeed. The Centers for Disease Control and Prevention recommends that mothers with HIV not breastfeed because they can pass the HIV through their breast milk to the baby. It is not known if SYNDROS passes into your breast milk. Talk to your doctor about the best way to feed your baby if you take SYNDROS. Do not breastfeed while taking SYNDROS and for 9 days after your last dose of SYNDROS if you are being treated for nausea and vomiting caused by anti-cancer medicine.
TELL YOUR DOCTOR ABOUT ALL THE MEDICINES YOU TAKE OR HAVE TAKEN IN THE LAST 14 DAYS, including prescription and over-the-counter medicines, vitamins, and herbal supplements. syndros and certain other medicines can affect each other, causing serious side effects.

How should I take SYNDROS?

  • See the “Instructions for Use” at the end of the Patient Information for detailed instructions about the right way to take SYNDROS.
  • Always use the oral syringe that comes with your SYNDROS oral solution to measure your prescribed dose. Ask your doctor or pharmacist to show you how to measure your prescribed dose.
  • Take SYNDROS exactly as your doctor tells you to. Your doctor may change your dose after seeing how it affects you. Do not change your dose unless your doctor tells you to change it.
  • Drink a full glass of water (6 to 8 ounces) right after you take your prescribed dose of SYNDROS oral solution.
  • If you are an adult with AIDS with loss of appetite and weight loss:
    • SYNDROS is usually taken 2 times each day, 1 hour before lunch and 1 hour before dinner. If you are elderly, or unable to tolerate this dose of SYNDROS, your doctor may prescribe SYNDROS to be taken 1 time each day, 1 hour before dinner or bedtime.
  • If you are an adult with nausea and vomiting caused by anti-cancer medicine:
    • SYNDROS is usually taken 1 to 3 hours before your chemotherapy treatment and then every 2 to 4 hours after chemotherapy for up to 4 to 6 doses each day. If you are elderly, your doctor may prescribe SYNDROS to be taken 1 to 3 hours before your chemotherapy, 1 time each day.
    • Take your first dose of SYNDROS on an empty stomach at least 30 minutes before eating. After your first dose of SYNDROS, you can take SYNDROS with or without food.
    • After your doctor has decided the dose of SYNDROS that is right for you, take SYNDROS exactly at the same time before or after meals during future chemotherapy treatment.
  • If you take too much SYNDROS, call your Poison Control Center at 1-800-222-1222 right away or go to the nearest emergency room.

What should I avoid while taking SYNDROS?

  • Do not drive, operate machinery, or do other dangerous activities until you know how SYNDROS affects you. SYNDROS taken with medicines that cause dizziness, confusion, and sleepiness may make these symptoms worse.

What is the most important information I should know about SYNDROS?

SYNDROS can cause serious side effects, including:

  • Worsening mental (psychiatric) symptoms. Psychiatric symptoms can worsen in adults who have mania, depression, or schizophrenia and who take SYNDROS. SYNDROS taken with medicines that cause psychiatric symptoms can worsen psychiatric symptoms. Elderly people who take SYNDROS may have a greater risk of having psychiatric symptoms. Tell your doctor if you have new or worsening mood symptoms, including symptoms of mania, depression, or schizophrenia.
  • Problems thinking clearly. Tell your doctor if you have trouble remembering things, concentrating, have increased sleepiness, or confusion. Elderly people may have a greater risk of having problems thinking clearly.
  • Changes in your blood pressure. SYNDROS may increase or decrease your blood pressure, especially when you start taking SYNDROS or when your dose is changed. Tell your doctor if you have signs or symptoms of changes in your blood pressure including: headaches, vision problems, dizziness, feeling lightheaded, fainting, or a fast heartbeat. Elderly people, especially those with dementia, and people with heart problems may have an increased risk of changes in blood pressure and an increased risk of falls.
  • Interactions with disulfiram or metronidazole. SYNDROS contains alcohol, which can cause you to have a reaction to medicines that contain disulfiram or metronidazole. You should not use any medicine that contains disulfiram (Antabuse) or metronidazole (Pylera, Flagyl, Flagyl ER, Nuvessa, Vandazole) if you take SYNDROS. You should not use a medicine that contains disulfiram or metronidazole for at least 14 days before you start taking SYNDROS and within 7 days after your last dose of SYNDROS. Tell your doctor if you have signs or symptoms of a reaction to disulfiram or metronidazole including: stomach-area (abdominal) cramping, nausea, vomiting, headache, and flushing.

What are the possible side effects of SYNDROS?

SYNDROS may cause serious side effects, including:

  • See “What is the most important information I should know about SYNDROS?”
  • Seizures. SYNDROS may increase your risk of seizures. Stop taking SYNDROS and call your doctor and get medical care right away if you have a seizure during treatment with SYNDROS.
  • Drug and alcohol abuse. You may have an increased risk of abusing SYNDROS if you have a history of drug or alcohol abuse or dependence, including marijuana. Tell your doctor if you develop abuse behaviors such as increased irritability, nervousness, restlessness or want more or higher doses of SYNDROS during your treatment.
  • Nausea, vomiting, or stomach-area (abdominal) pain. Tell your doctor if you have nausea, vomiting, or abdominal pain or if your nausea, vomiting, or abdominal pain gets worse during treatment with SYNDROS.

THE MOST COMMON SIDE EFFECTS OF SYNDROS INCLUDE:

  • stomach-area (abdominal) pain
  • dizziness
  • feeling extremely happy (euphoria)
  • nausea
  • overly suspicious or feeling people want to harm you (paranoid reaction)
  • sleepiness
  • abnormal thoughts
  • vomiting

THESE ARE NOT ALL THE POSSIBLE SIDE EFFECTS OF SYNDROS.

General information about the safe and effective use of SYNDROS

DO NOT USE SYNDROS FOR A CONDITION FOR WHICH IT WAS NOT PRESCRIBED. DO NOT GIVE SYNDROS TO OTHER PEOPLE, EVEN IF THEY HAVE THE SAME SYMPTOMS THAT YOU HAVE. IT MAY HARM THEM. YOU CAN ASK YOUR DOCTOR OR PHARMACIST FOR INFORMATION ABOUT SYNDROS THAT IS WRITTEN FOR HEALTH PROFESSIONALS.
Tell your healthcare provider about all the medicines and supplements you take, as some medicines may affect how SYNDROS works. Benuvia encourages you to report negative side effects of prescription drugs. To report SUSPECTED ADVERSE REACTIONS, contact Benuvia Operations, LLC at 1-844-558-8289 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
SYNDROS® is a registered trademark of Benuvia Operations, LLC.
©2023 Benuvia Operations, LLC. All rights reserved.

SYNDROS® is a registered trademark of Benuvia Operations, LLC.
©2023 Benuvia Operations, LLC. All rights reserved.
Terms and Conditions | Privacy Policy

Benuvia Logo by Aaron Ball